Long-term single-molecule Ca2+ flux recordings reveal mode-switching regulation of Ca2+-ATPases
Mads P. Møller, Aleksander Cvjetkovic, Eleftherios Kosmidis, Alessandra Narducci, Michael Isselstein, Christopher G. Shuttle, Bo Højen Justesen, Ida Louise Jørgensen, Sara Basse Hansen, Mateusz Dyla, Jesper Holmkvist, Magnus Kjærgaard, Per Amstrup Pedersen, Poul Nissen, Thomas Günther Pomorski, Dimitrios G. Stamou
This study uses single-molecule recordings to show Ca2+-ATPases switch between active and inactive modes, revealing a new regulatory mechanism for Ca2+ homeostasis.
bioRxiv · Jan 31, 2026 · PreprintBiophysics