Author

Aravintha Siva

University of MichiganORCID 0000-0001-8457-4965Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

John P. GilliesiD· 2 shared Morgan E. DeSantisiD· 2 shared Ashley de BorchgraveiD· 1 shared Cameron Conklin· 1 shared Daytan GibsoniD· 1 shared Juliana L. ZangiD· 1 shared Reagan S Clarke· 1 shared Rishi Mishra· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiophysics

John P. GilliesORCID

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2 papers

Recent·Most cited

BiophysicsDOAJ (DOAJ: Directory of Open Access Journals)Peer-reviewedAug 8, 2026

Synthetic cargo adaptors reveal molecular features that can enhance dynein activation

Aravintha Siva, John P. Gillies, Ashley de Borchgrave…·Morgan E. DeSantis

This study engineers synthetic cargo adaptors to investigate how they modulate dynein activation and transport properties in vitro and in cells.

DOI 10.1038/s41467-026-76181-4

experimental assaycell signaling & trafficking

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BiophysicsJournal of Biological ChemistryPeer-reviewedFeb 26, 2025

Cargo adaptor identity controls the mechanism and kinetics of dynein activation

John P. Gillies, Saffron R. Little, Aravintha Siva…·Morgan E. DeSantis

The paper investigates how different cargo adaptors influence the kinetics and mechanism of dynein-dynactin complex formation, revealing distinct assembly pathways and stable tripartite complexes.

9 citationstop 5%

experimental assay

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