Sidney H. Wang

This study evaluates combinatorial CRISPR/Cas12a for locus excision in mammalian cells and finds low efficiency despite targeting intronic regions.

The paper identifies eQTLs, rQTLs, and pQTLs in the human brain and shows that many eQTL effects are attenuated post-transcriptionally, yet still correlate with schizophrenia GWAS signals.

The paper evaluates deconvolution methods on human brain data, finding dtangle and bMIND perform best, and identifies decon-eQTLs that explain more schizophrenia heritability than bulk or single-cell eQTLs.

This paper introduces spike-in oligomers for accurate ribosome profiling under acute stress and evaluates normalization methods for stress-induced translation changes.

The paper introduces the in4mer CRISPR/Cas12a platform for efficient multiplex gene knockout, demonstrating improved sensitivity and reduced clone numbers compared to CRISPR/Cas9.

This study examines how genetic background and cell lineage influence position effect variegation in Drosophila, finding that genotype explains most differences in silencing levels and that cell lineage affects expression patterns.