Author
Broad InstituteORCID 0009-0005-7657-8372Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Nazanin Esmaeili Anvar, Zsofia M Szegletes, Ryan J. Steger…·Traver Hart
This study evaluates combinatorial CRISPR/Cas12a for locus excision in mammalian cells and finds low efficiency despite targeting intronic regions.
E L Kaplan, Ryan J. Steger, Spencer T. Shah…·John G. Doench
This paper introduces an activity-based selection method to improve base editing efficiency and precision in identifying functional mutations.
Abby V. McGee, Yanjing V. Liu, Audrey L Griffith…·John G. Doench
The paper introduces a modular CRISPR vector assembly system called Fragmid, enabling rapid creation and testing of CRISPR technologies through combinatorial design and pooled screening.