Hannah E. Olsen

This study identifies a transcriptional mechanism that controls oligodendrocyte maturation through SOX6-mediated gene melting, showing that suppressing SOX6 accelerates maturation and that an immature SOX6 signature is enriched in multiple sclerosis patient brains.

This paper shows that reducing PLP1 expression in a mouse model of PMD improves myelination, motor function, and lifespan, supporting PLP1 suppression as a therapeutic strategy.