Maria Pennuto

This study identifies how the polyglutamine tract in the androgen receptor regulates muscle growth and atrophy by altering transcriptional activity and chromatin binding.

The paper identifies cryptic phosphosites in the human proteome that are buried in the protein core and may influence folding and degradation, with implications for cancer.

This study shows polyglutamine-expanded androgen receptor disrupts muscle function by altering calcium dynamics and excitation-contraction coupling gene expression, which can be reversed by treatment.