Leonardo Nogara

This study shows mitochondrial dysfunction accelerates aging by disrupting gut microbiota structure and inducing immune dysregulation and inflammation through metabolic reprogramming.

This study shows that disrupting peroxisomal-mitochondrial interactions in skeletal muscle accelerates muscle dysfunction and age-related degeneration.

This study shows that ANTXR2 regulates COL6 turnover in skeletal muscle, and its deficiency leads to ECM stiffening and muscle dysfunction.

This study shows phosphatases control the duration and spatial range of cAMP/PKA microdomains by limiting phosphorylated PKA target activity.

This study shows polyglutamine-expanded androgen receptor disrupts muscle function by altering calcium dynamics and excitation-contraction coupling gene expression, which can be reversed by treatment.