A Cellular Basis for Heightened Gut Sensitivity in Females
Archana Venkataraman, Eric E. Figueroa, Joel Castro, F Navarro, Deepanshu Soota, Stuart M. Brierley, David J. Julius, Holly A. Ingraham
The paper identifies an estrogen-responsive paracrine pathway in the gut that increases sensitivity in females by enhancing communication between enteroendocrine cells and sensory nerves.
Science · Dec 18, 2025Peer-reviewedPhysiology