Joel Castro

The paper identifies an estrogen-responsive paracrine pathway in the gut that increases sensitivity in females by enhancing communication between enteroendocrine cells and sensory nerves.

This study identifies IL-33 as a key mediator in endometriosis pain and lesion formation through neuroimmune communication involving CGRP and macrophages.

This study identifies distinct roles for crypt and villus enterochromaffin cells in sensing gut irritants and oxidative stress through different TRP channels and signaling mechanisms.

This study identifies MrgprA3 and MrgprC11 as functional receptors on bladder afferents that induce hypersensitivity to distension when activated, offering a potential therapeutic target for bladder disorders.