Stuart M. Brierley

The paper identifies a hypothalamic-hindbrain circuit in mice that suppresses excretion and pelvic pain during movement, enhancing mate-seeking behavior.

The paper identifies an estrogen-responsive paracrine pathway in the gut that increases sensitivity in females by enhancing communication between enteroendocrine cells and sensory nerves.

This study identifies IL-33 as a key mediator in endometriosis pain and lesion formation through neuroimmune communication involving CGRP and macrophages.

This study identifies distinct brainstem circuits activated by splanchnic and pelvic spinal afferent pathways from the mouse colorectum, showing their differential roles in sensory processing and visceromotor responses.

The paper designs proteins that bind intrinsically disordered regions with high affinity and specificity across diverse targets.

This study investigates how CaV2.2, GIRK, and HCN channels modulate excitability in somatic and visceral sensory neurons in response to Vc1.1 and baclofen, finding distinct mechanisms in different neuron types.

This study identifies distinct roles for crypt and villus enterochromaffin cells in sensing gut irritants and oxidative stress through different TRP channels and signaling mechanisms.

This study identifies MrgprA3 and MrgprC11 as functional receptors on bladder afferents that induce hypersensitivity to distension when activated, offering a potential therapeutic target for bladder disorders.