David J. Julius

The paper identifies an estrogen-responsive paracrine pathway in the gut that increases sensitivity in females by enhancing communication between enteroendocrine cells and sensory nerves.

The paper identifies ETC regulation as a protective mechanism against excitotoxicity in TRPV1+ sensory neurons using CRISPRi screening and functional experiments.

This study uses cryo-EM and HDX-MS to reveal structural changes in TRPM8 channels that underlie cold sensitivity and menthol activation.

This study identifies distinct roles for crypt and villus enterochromaffin cells in sensing gut irritants and oxidative stress through different TRP channels and signaling mechanisms.

This study identifies a kappa opioid signaling pathway that regulates ependymal cell proliferation in the spinal cord, with implications for scar formation and injury recovery.