Mariann Koel

Targeted gene expression profiling for accurate endometrial receptivity testing

The paper develops a targeted gene expression assay to assess endometrial receptivity, finding higher rates of shifted window of implantation in recurrent implantation failure patients.

Genome-wide association study identifies five risk loci for pernicious anemia and implicates the role of HLA-DR15 haplotype

This study identifies five genetic risk loci for pernicious anemia through a genome-wide association analysis and links the disease to the HLA-DR15 haplotype.

GWAS meta-analysis and gene expression data link reproductive tract development, immune response and cellular proliferation/apoptosis with cervical cancer and clarify overlap with other cervical phenotypes

The paper performs a GWAS meta-analysis of cervical cancer and links it to reproductive tract development, immune response, and cellular proliferation/apoptosis, while also identifying genetic risk factors for other cervical phenotypes.

TAC-seq: targeted DNA and RNA sequencing for precise biomarker molecule counting

TAC-seq is a targeted sequencing method using UMIs to count biomarker molecules, showing improved accuracy in mRNA, microRNA, and cell-free DNA analysis compared to standard sequencing.

Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity

The paper investigates how cellular composition affects endometrial gene expression profiles and shows that adjusting for cell proportions changes differential expression results.