Signe Altmäe

Microbial-derived D-lactate and LPS shape growth and inflammatory signalling in endometrial glandular epithelium

This study investigates how microbial compounds D-lactate and LPS affect endometrial epithelial function using organoids, showing distinct gene expression changes related to growth and inflammation.

Comprehensive 16S rRNA gene sequencing and meta-transcriptomic analyses in female reproductive tract microbiota: Two molecular profiles with different messages

This study compares 16S rRNA gene sequencing and meta-transcriptomic analyses of endometrial microbiota, finding weak correlation in low-biomass environments and highlighting the value of RNA-based functional insights.

Multi-ancestry genome-wide association study of endometriosis and its clinical manifestations in ~1.4 million women: translating gene discovery into pathogenic mechanisms and therapeutic targets

This study identifies 80 genome-wide significant associations for endometriosis and adenomyosis in 1.4 million women, uncovering novel loci and pathways involved in disease mechanisms.

Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity

The paper investigates how cellular composition affects endometrial gene expression profiles and shows that adjusting for cell proportions changes differential expression results.