Metabolic reprogramming by caloric restriction enhances acute phase virological control and reduces chronic inflammation in SIV-infected rhesus macaques
Naveen Suresh Babu, Chrysostomos Perdios, Maggie Hallmets, Anna T. Brown, Celeste D. Coleman, Christine M. Fennessey, Carolina Allers, Matilda J. Moström, Pratik Khare, Cissy Zhang, Brandon Smith, Nadia Golden, Adam Myers, Lara A. Doyle‐Meyers, Alexandra Blaney, , Joseph C. Mudd
This study shows that caloric restriction in SIV-infected rhesus macaques reduces acute viremia, dampens inflammation, and improves metabolic function, but does not affect viral persistence.
bioRxiv · Mar 12, 2026 · PreprintImmunology