Christine M. Fennessey

Durable protection against SIV challenge by adeno-associated virus delivery of Env-specific antibodies

AAV-delivered broadly neutralizing antibodies provide durable protection against SIV challenge in rhesus macaques, while ADCC-only antibodies do not.

Metabolic reprogramming by caloric restriction enhances acute phase virological control and reduces chronic inflammation in SIV-infected rhesus macaques

This study shows that caloric restriction in SIV-infected rhesus macaques reduces acute viremia, dampens inflammation, and improves metabolic function, but does not affect viral persistence.

Dissecting the steps in early Simian Immunodeficiency Virus dissemination following mucosal and intravenous infection of rhesus macaques

This study uses a barcoded SIV infection model to analyze the dissemination bottleneck in rhesus macaques, finding anatomical heterogeneity contributes most to early viral spread variability.

Origin and Correlates of Viral Rebound in SIV-Infected Rhesus Macaques Following ART Discontinuation

This study identifies the origin and dynamics of viral rebound in SIV-infected macaques after ART discontinuation, showing local tissue replication and systemic expansion of clonal lineages.

Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy

This study shows that delivering Env-specific antibodies via AAV prevents SIV rebound in macaques after stopping ART.

RhCMV Expands CCR5 Memory T Cells and promotes SIV reservoir seeding in the Gut Mucosa

HIV-1 control in vivo is related to the number but not the fraction of infected cells with viral unspliced RNA

The paper compares the fraction and total number of HIV-infected cells with unspliced RNA in controllers and non-controllers, finding that viremic control is linked to fewer infected cells, not a lower fraction of infected cells with HIV usRNA.