Author

Laëtitia Lesage

Institut CurieORCID 0000-0001-8592-2482Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Christine SedlikiD· 2 shared Eliane PiaggioiD· 2 shared Federico MarzialiiD· 2 shared Franck BourdeautiD· 2 shared Jérémie D. GoldsteiniD· 2 shared Jimena ToselloiD· 2 shared Jordan Denizeau· 2 shared Joshua J. WaterfalliD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Christine SedlikORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologybioRxivPreprintDec 29, 2025

Myeloid reprogramming by poly(I:C) recruits progenitor-exhausted CD8+ T cells and sensitizes rhabdoid tumors to PD-1 blockade

Valeria Sandoval Manríquez, Sofia Cavada-Silva, Kévin Beccaria…·Eliane Piaggio

This study shows that poly(I:C) reprograms myeloid cells in rhabdoid tumors, enhancing CD8+ T cell infiltration and improving response to PD-1 blockade.

DOI 10.64898/2025.12.29.696858

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintDec 22, 2025

Analysis of intratumoral immune heterogeneity reveals spatial organisation of immunosuppression in breast cancer

Christina Metoikidou, Pierre‐Emmanuel Bonté, Vadim K Karnaukhov…·Sebastián Amigorena

This study maps spatial immune heterogeneity in luminal breast cancer, showing progressive immunosuppression from tumor margins to core.

DOI 10.64898/2025.12.18.694622

humanscRNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintDec 17, 2025

Dual PD-L1/TIGIT blockade induces PNAd+ HEV-like vessels and CD62L+ lymphocyte recruitment, driving rhabdoid tumor rejection

Stéphanie Fitte-Duval, S Silva, Rafael Mena‐Osuna…·Eliane Piaggio

This study shows that combining PD-L1 and TIGIT blockade in a mouse model of rhabdoid tumors leads to tumor regression by promoting immune cell recruitment and vascular changes.

DOI 10.64898/2025.12.15.692132

mousebulk RNA-seq

𝕏 PostBluesky