Jimena Tosello

This study shows that poly(I:C) reprograms myeloid cells in rhabdoid tumors, enhancing CD8+ T cell infiltration and improving response to PD-1 blockade.

This study shows that combining PD-L1 and TIGIT blockade in a mouse model of rhabdoid tumors leads to tumor regression by promoting immune cell recruitment and vascular changes.

The paper identifies a common origin for effector and regulatory CD4+ T cells in non-small cell lung cancer through single-cell analysis, revealing their plasticity and role in immune responses.

This study shows that blocking TNFR2 reduces Treg activity and T cell exhaustion in PDAC, with improved efficacy when combined with CD40 agonists.