Sebastián Amigorena

This study maps spatial immune heterogeneity in luminal breast cancer, showing progressive immunosuppression from tumor margins to core.

The paper traces the evolutionary impact of transposons on human inflammatory enhancers and shows their role in disease susceptibility through population genetics analysis.

The paper introduces DivisionCounter, a method to count large cell divisions in vivo, showing leukemia tumor division rates are independent of microenvironment and CAR-T treatment.

This study shows that SUV39H1 depletion in CD8+ T cells enhances tissue homing and TRM differentiation, improving therapeutic outcomes in infection and cancer.