Author

Karen S. Keslar

Cleveland ClinicORCID 0000-0001-8609-4797Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Robert L. FairchildiD· 3 shared Danielle D. KishiD· 2 shared Nina DvorinaiD· 2 shared William M. BaldwiniD· 2 shared Brian D. SoutherniD· 1 shared Chengsong ZhuiD· 1 shared Daigo OkadaiD· 1 shared Erik H. KoritzinskyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

Robert L. FairchildORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintMar 5, 2026

NK Cells Effectively Mediating Antibody-Mediated Kidney Allograft Rejection Requires a Specific Activation Receptor and Graft Expression of the Ligand

Yuki Maruyama, Daigo Okada, Hidetoshi Tsuda…·Robert L. Fairchild

This study shows that NK cell activation via NKG2D and graft Rae-1e ligand is essential for antibody-mediated kidney allograft rejection, even with high DSA levels.

DOI 10.64898/2026.03.03.709363

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintSep 28, 2025

NK cell allorecognition shapes reprogramming of neutrophils infiltrating heart allografts

Erik H. Koritzinsky, Karen S. Keslar, Robert L. Fairchild, Jayati Mookerjee Basu

This study shows that NK cell allorecognition reprograms neutrophils in heart allografts, leading to a novel hybrid neutrophil subset that may impact transplant outcomes.

DOI 10.1101/2025.09.28.679079

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintJun 11, 2025

Inhibition of De Novo Autoantibody Production Attenuates Chronic Antibody-Mediated Rejection of Kidney Allografts Despite Maintenance of High Donor-Specific Antibody Titers

Yosuke Mitsui, Karen S. Keslar, Michael Nicosia…·Robert L. Fairchild

The paper shows that inhibiting de novo autoantibody production reduces chronic antibody-mediated rejection of kidney allografts, even when donor-specific antibody titers remain high.

1 citation

mouseproteomics

𝕏 PostBluesky