Author

William M. Baldwin

Cleveland ClinicORCID 0000-0002-7271-1827Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Robert L. FairchildiD· 3 shared Danielle D. KishiD· 2 shared Karen S. KeslariD· 2 shared Nina DvorinaiD· 2 shared Anat R. TamburiD· 1 shared Brian D. SoutherniD· 1 shared Chengsong ZhuiD· 1 shared Daigo OkadaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

Robert L. FairchildORCID

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3 papers

Recent·Most cited

NK Cells Effectively Mediating Antibody-Mediated Kidney Allograft Rejection Requires a Specific Activation Receptor and Graft Expression of the Ligand

Yuki Maruyama, Daigo Okada, Hidetoshi Tsuda, Danielle D. Kish, Karen S. Keslar, Nina Dvorina, William M. Baldwin, Robert L. Fairchild

This study shows that NK cell activation via NKG2D and graft Rae-1e ligand is essential for antibody-mediated kidney allograft rejection, even with high DSA levels.

bioRxiv · Mar 5, 2026 · PreprintImmunology

Inhibition of De Novo Autoantibody Production Attenuates Chronic Antibody-Mediated Rejection of Kidney Allografts Despite Maintenance of High Donor-Specific Antibody Titers

Yosuke Mitsui, Karen S. Keslar, Michael Nicosia, Danielle D. Kish, Nina Dvorina, Chengsong Zhu, Mitchell A. Olman, Brian D. Southern, William M. Baldwin, Robert L. Fairchild

The paper shows that inhibiting de novo autoantibody production reduces chronic antibody-mediated rejection of kidney allografts, even when donor-specific antibody titers remain high.

bioRxiv · Jun 11, 2025 · PreprintImmunology

Compartmentalization of Transcripts During Antibody Mediated Rejection in Renal Transplants

Dajana Margeta, Hirotsugu Noguchi, Sepideh Khazaie, Leal C. Herlitz, Joshua J. Augustine, Peter S. Heeger, Anat R. Tambur, Robert L. Fairchild, William M. Baldwin

The paper uses Digital Spatial Profiling to analyze transcript localization in renal transplant biopsies, showing compartmentalized immune responses and persistent podocyte transcript reduction during antibody-mediated rejection.

Clinical Immunology · May 22, 2024Peer-reviewedPathology