Author

Constanza Savid-Frontera

Moffitt Cancer CenterORCID 0000-0001-8614-3528Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Marco L. DavilaiD· 2 shared Michael David JainiD· 2 shared Abdessamad A. Youssfi· 1 shared Alexander R.A. AndersoniD· 1 shared Anthony Augello· 1 shared Austin Daniel NewsamiD· 1 shared Bachisio ZicchedduiD· 1 shared Catalina C Amador· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Marco L. DavilaORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 27, 2026

Lymphoma response to chimeric antigen receptor T cell therapy is driven by endogenous tumor-reactive CD8⁺ T cells

Bachisio Ziccheddu, Constanza Savid-Frontera, Venu V.G. Saralamma…·Frederick Lundry Locke

This study shows that durable CAR-T therapy in lymphoma requires cooperation with endogenous CD8 T cells, and tumors lacking MHC class I or CD58 resist treatment.

DOI 10.64898/2026.10.23.761341

humanwhole-genome sequencing

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Cancer BiologybioRxivPreprintMar 6, 2025

The Th1/Th17 axis regulates chimeric antigen receptor (CAR) T cell therapy toxicities

Payal Goala, Yongliang Zhang, Nolan Beatty…·Marco L. Davila

This study identifies a Th1/Th17 imbalance driven by IFN{gamma} that causes cytokine release syndrome and neutropenia in CAR-T therapy, suggesting IFN{gamma} blockade as a potential treatment.

1 citation

mousehuman

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