The Th1/Th17 axis regulates chimeric antigen receptor (CAR) T cell therapy toxicities
Payal Goala, Yongliang Zhang, Nolan Beatty, Shannon L. McSain, Cooper J. Sailer, Muhammad Junaid Tariq, Showkat Hamid, Eduardo Cortes Gomez, Jianmin Wang, Justin C. Boucher, Constanza Savid-Frontera, Sae Bom Lee, Hiroshi Kotani, Michael David Jain, Marco L. Davila
This study identifies a Th1/Th17 imbalance driven by IFN{gamma} that causes cytokine release syndrome and neutropenia in CAR-T therapy, suggesting IFN{gamma} blockade as a potential treatment.
bioRxiv · Mar 6, 2025 · PreprintCancer Biology