Caroline J. Aufgebauer

Modulator processes nanopore direct-RNA sequencing data to differentiate transcript-, allele-, and condition-associated RNA modifications, improving the analysis of RNA modifications in single molecules.

The paper identifies CSTF2 and CSTF2T as factors that shape the m6A landscape through cleavage-dependent and -independent mechanisms by altering transcript architecture and polyadenylation sites.

The paper introduces a small cationic probe, TMO, to detect RNA tertiary structures by identifying electronegative motifs that react selectively with TMO, revealing functional tertiary interaction sites.

This study shows UFMylation enhances orthoflavivirus infection by promoting virion assembly, but not RNA replication or translation.