Author

Xiaodan Li

Paul Scherrer InstituteORCID 0000-0001-8647-7317Unclaimed ORCID profile · follow to get notified of new preprints

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Xiaodan Li1 paper

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Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1

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Anand VaithiaiD· 1 shared Basavraj KhanppnavariD· 1 shared Dina SchusteriD· 1 shared Francesco Luigi GervasioiD· 1 shared Paola PicottiiD· 1 shared Pia LavrihaiD· 1 shared Simone AureliiD· 1 shared Thorsten B. BlumiD· 1 shared

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1 shared paperBiophysics

Anand VaithiaORCID

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1 paper

Recent·Most cited

BiophysicsCell DiscoveryPeer-reviewedJun 18, 2024

Structural basis of connexin-36 gap junction channel inhibition

Xinyue Ding, Simone Aureli, Anand Vaithia…·Volodymyr M. Korkhov

The paper reports the cryo-EM structure of connexin-36 bound to mefloquine, revealing how small molecules inhibit gap junction channels by partially occluding the pore and altering electrostatics.

13 citations

cryo-EMexperimental assay

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