Author

Xinyue Ding

Paul Scherrer InstituteORCID 0000-0003-1375-9473Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Anand VaithiaiD· 2 shared Dina SchusteriD· 2 shared Paola PicottiiD· 2 shared Pia LavrihaiD· 2 shared Volodymyr M. KorkhoviD· 2 shared Basavraj KhanppnavariD· 1 shared Chao QiiD· 1 shared Francesco Luigi GervasioiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

Anand VaithiaORCID

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2 papers

Recent·Most cited

BiochemistryPLoS ONEPeer-reviewedDec 31, 2024

Mechanism of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate

Pia Lavriha, Yufei Han, Xinyue Ding…·Volodymyr M. Korkhov

The paper identifies two distinct binding sites for connexin channel inhibitors mefloquine and 2APB, showing they block channel function through different mechanisms.

6 citations

experimental assay

𝕏 PostBluesky

BiophysicsCell DiscoveryPeer-reviewedJun 18, 2024

Structural basis of connexin-36 gap junction channel inhibition

Xinyue Ding, Simone Aureli, Anand Vaithia…·Volodymyr M. Korkhov

The paper reports the cryo-EM structure of connexin-36 bound to mefloquine, revealing how small molecules inhibit gap junction channels by partially occluding the pore and altering electrostatics.

13 citations

cryo-EMexperimental assay

𝕏 PostBluesky