Andrés F. Vallejo

Human CD1c-autoreactive T cells recognise Mycobacterium tuberculosis-infected antigen-presenting cells and display cytotoxic effector programmes

This study shows CD1c-autoreactive T-cells recognize Mtb-infected APCs, exhibit cytotoxicity, and reduce Mtb burden through CD1c-dependent mechanisms.

snPATHO-seq: unlocking the pathology archives

This study introduces a method to generate high-quality single-nucleus transcriptomic data from FFPE samples using recent single-cell genomic technology.

Rank Selection Genetic Algorithm optimises robust parameter estimation for systems biology models

This paper introduces GARS, a genetic algorithm with rank selection, for parameter estimation in biological models, showing strong accuracy and superiority over existing methods.

Distinct immune responses in patients infected with influenza or SARS-CoV-2, and in COVID-19 survivors, characterised by transcriptomic and cellular abundance differences in blood.

The paper compares immune responses in influenza and SARS-CoV-2 infected patients and COVID-19 survivors using transcriptomic data, identifying distinct immune signatures and prognostic indicators.

TNF signalling fine-tunes Langerhans cell transcriptional programmes mediating adaptive immunity.

The paper identifies TNF-driven transcriptional programs in Langerhans cells that regulate immunogenic and tolerogenic responses through IRF1 and other transcription factors.

Resolving cellular systems by ultra-sensitive and economical single-cell transcriptome filtering

The paper introduces C-DropSeq, a method that improves sensitivity in single-cell transcriptomics by reducing sequencing depth and costs, and demonstrates its application in identifying rare dendritic cell sub-populations.

Single cell transcriptomic analysis identifies Langerhans cells immunocompetency is critical for ability to induce tolerogenic T cells.

The paper identifies that Langerhans cells (LCs) upregulate a tolerogenic gene module during migration, which is critical for inducing regulatory T cells.