Roshanak Irannejad

This paper develops spatially restricted antagonists to selectively inhibit β1AR signaling at the plasma membrane versus intracellular compartments, revealing compartment-specific effects on downstream signaling.

This study shows that anionic phospholipids like PI(4,5)P2 enable promiscuous GPCR coupling to both cognate and non-cognate G proteins at the plasma membrane, while restricting coupling to cognate G proteins in other compartments.