Andrew Thrasher

The paper shows that mutant allele enrichment in bulk tumor RNA can be confounded by tumor purity and NMD, and demonstrates RNA-Seq can improve driver indel detection.

MethylationToActivity infers promoter activity from DNA methylation data in tumors, showing high accuracy across multiple cancer types.

XenoCP is a cloud-based tool that removes mouse reads from xenograft BAM files to improve RNA-seq and WGS analysis accuracy.