Nobuhisa Iwata

This study compares the effects of TREM2 R47H mutation and TREM2 deficiency in aged AppNL-F mice, finding that the mutation causes mild, functionally distinct microglial changes compared to a null effect.

This paper investigates the metabolic stability and deposition of A{beta}3pE-42, a target of the Alzheimer's antibody donanemab, showing it is more stable than other A{beta}X-42 species and accumulates with age.

This study compares the roles of NEP and IDE in Aβ metabolism using double knockout mice, finding NEP primarily degrades insoluble Aβ and its deficiency contributes to AD pathology.