NeuroscienceExperimental NeurologyPeer-reviewed
Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged AppNL-F knock-in mice
Keiro Shirotani, Daisuke Hatta, Kaori Watanabe…·Nobuhisa Iwata
This study compares the effects of TREM2 R47H mutation and TREM2 deficiency in aged AppNL-F mice, finding that the mutation causes mild, functionally distinct microglial changes compared to a null effect.
DOI 10.1016/j.expneurol.2026.115894