Author

Satoshi Tsubuki

RIKEN Center for Brain Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:differential expression· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Hiroki SasaguriiD· 4 shared Naomasa Kakiya· 4 shared Naoto WatamuraiD· 4 shared Takaomi C. SaidoiD· 4 shared Takashi SaitoiD· 4 shared Misaki Sekiguchi· 3 shared Risa TakamuraiD· 3 shared Shoko HashimotoiD· 3 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Hiroki SasaguriORCID

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4 papers

Recent·Most cited

Metabolic resistance of Abeta3pE-42, epitope of the anti-Alzheimer therapeutic antibody, donanemab.

Nobuhisa Iwata, Satoshi Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata, Yukio Matsuba, Naoko Kamano, Ryo Fujioka, Risa Takamura, Naoto Watamura, Naomasa Kakiya, Naomi Mihira, Takahiro Morito, Keiro Shirotani, David M. A. Mann, Andrew Robinson, , Takaomi C. Saido

This paper investigates the metabolic stability and deposition of A{beta}3pE-42, a target of the Alzheimer's antibody donanemab, showing it is more stable than other A{beta}X-42 species and accumulates with age.

Life Science Alliance · Sep 30, 2024Peer-reviewedNeuroscience

Neprilysin-sensitive amyloidogenic Aβ versus IDE-sensitive soluble Aβ: a probable mechanistic cause for sporadic Alzheimer's disease

Hiroki Sasaguri, Risa Takamura, Naoto Watamura, Naomasa Kakiya, Toshio Ohshima, Ryo Fujioka, Naomi Yamazaki, Misaki Sekiguchi, Kaori Iwata, Yukio Matsuba, Shoko Hashimoto, Satoshi Tsubuki, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido

This study compares the roles of NEP and IDE in Aβ metabolism using double knockout mice, finding NEP primarily degrades insoluble Aβ and its deficiency contributes to AD pathology.

bioRxiv · Aug 22, 2021 · PreprintNeuroscience

α-Endosulfine regulates amyloid β42 via the modulation of neprilysin activity

Naoto Watamura, Naomasa Kakiya, Per Nilsson, Satoshi Tsubuki, Naoko Kamano, Mika Takahashi, Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, Takaomi C. Saido

This study identifies α-endosulfine as a negative regulator of neprilysin activity, showing that its deficiency reduces amyloid β42 deposition in Alzheimer's disease models.

bioRxiv · Oct 7, 2020 · PreprintNeuroscience

Somatostatin receptor subtypes 1 and 4 redundantly regulate neprilysin, the major amyloid beta-degrading enzyme, in brain

Per Nilsson, Karin Margareta Sörgjerd, Naomasa Kakiya, Hiroki Sasaguri, Naoto Watamura, Makoto Shimozawa, Satoshi Tsubuki, Zhulin Zhou, Raúl Loera‐Valencia, Risa Takamura, Misaki Sekiguchi, Aline Petrich, Stefan Schulz, Takashi Saito, Bengt G. Winblad, Takaomi C. Saido

This study identifies SST1 and SST4 as redundant regulators of neprilysin, a key amyloid beta-degrading enzyme, and shows that targeting these receptors reduces Aβ pathology and improves cognition in an AD mouse model.

bioRxiv · May 9, 2020 · PreprintNeuroscience