Author

Youmian Yan

Washington University in St. LouisORCID 0000-0001-8733-6989Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:wet-lab / biochemical assay· 1 Organism:yeast· 1

Frequent Co-Authors

Natalie M. NiemiiD· 2 shared Alex S. HolehouseiD· 1 shared Baigalmaa ErdenepureviD· 1 shared Ian R. CollinsoniD· 1 shared Keri‐Lyn KozuliD· 1 shared Lianjie WeiiD· 1 shared Maria BehrensiD· 1 shared Stephen P. PlassmeyeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Natalie M. NiemiORCID

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2 papers

Recent·Most cited

Combinatorial sequence elements fine-tune mitochondrial protein import to facilitate dual localization

Youmian Yan, Lianjie Wei, Thomas Schödl, Keri‐Lyn Kozul, Maria Behrens, Stephen P. Plassmeyer, Alex S. Holehouse, Natalie M. Niemi

This study identifies sequence elements that enable dual localization of mitochondrial proteins, showing how combinatorial features regulate import and function across compartments.

bioRxiv · Aug 1, 2026 · PreprintBiochemistry

Mitochondrial presequences harbor variable strengths to maintain organellar function

Youmian Yan, Baigalmaa Erdenepurev, Thiago N. Menezes, Ian R. Collinson, Natalie M. Niemi

This study quantifies presequence strength in mitochondrial protein import and shows its impact on mitochondrial function and cellular fitness.

The Journal of Cell Biology · Dec 16, 2025Peer-reviewedBiochemistry