Ranjan Kumar Nanda

This study uses isotopic tracing to analyze metabolic differences in Mtb-infected cells, showing virulent and drug-resistant strains have distinct metabolic dependencies.

This study identifies transcriptomic changes in A549 lung cancer cells as they transition from non-confluent to confluent growth, revealing shifts in metabolic pathways and transporters.

This study shows that limiting sulfur availability in Mycobacterium tuberculosis increases its vulnerability to antibiotics and enhances drug efficacy in a mouse model.

This study shows methionine supplementation enhances pro-inflammatory responses and mycobacterial clearance in tuberculosis by modulating host metabolism and epigenetic pathways.

The paper identifies RvD5-GPR32 signaling as a mechanism by which TB-PE reprograms macrophage metabolism to impair anti-tuberculous immunity.

This study shows that phosphoglucomutase A (pgmA) is essential for Mycobacterium tuberculosis survival under nutrient-limiting conditions and disease persistence.

This study shows that time-restricted feeding improves metabolic health in mice but has limited effect on reducing Mycobacterium tuberculosis burden early after infection.

The paper investigates how sertraline enhances TB drug efficacy by modulating macrophage mitochondrial physiology and inflammasome activation.

This study investigates gut microbiome and metabolome changes in diabetic mice co-infected with tuberculosis, identifying dysbiosis and metabolic alterations associated with comorbidity.

This study examines how diabetes and tuberculosis co-morbid conditions alter macrophage differentiation and metabolic profiles, revealing perturbed pathways and immune responses.

This study shows that the VDR-calcium axis is critical for metabolic adaptation during weaning, with dietary fat preventing energy deprivation in VDR-deficient mice.

This study uses single-cell RNA-seq to show reduced type-II interferon and elevated Th17 responses in lung immune cells of diabetes-tuberculosis comorbid mice.

The paper analyzes copy number variations in 9,482 Mycobacterium tuberculosis isolates to identify lineage-specific molecular determinants associated with virulence and drug resistance.

This study shows that Mtb infection alters amino acid metabolism in non-pulmonary tissues of mice, with age-specific metabolic changes observed in different tissue types.