NeurosciencebioRxivPreprint
Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting cysteines in the C-terminal domain of GluN2B subunits: implications for synaptic plasticity
Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh…·Pierre Julius Magistretti
This study shows lactate enhances NMDA receptor currents through redox-sensitive cysteines in GluN2B and CaMKII interactions, linking astrocyte metabolism to synaptic plasticity.
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