Author

Lorène Mottier

King Abdullah University of Science and Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:electronic health records· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Adriano AguzziiD· 1 shared Alessandra Carrella· 1 shared Alessandro CrimiiD· 1 shared Alexandre P. A. TheocharidesiD· 1 shared Amanda OoiiD· 1 shared Andra ChincisaniD· 1 shared Andreia D. MagalhãesiD· 1 shared Andrey Y. AbramoviD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Adriano AguzziORCID

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2 papers

Recent·Most cited

Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting cysteines in the C-terminal domain of GluN2B subunits: implications for synaptic plasticity

Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh, Lorène Mottier, John Girgis, Carine Benadiba, Pascal Jourdain, Nicolò Carrano, Hanan Mahmood, Amanda Ooi, Stefan T. Arold, Mónica Di Luca, Fabrizio Gardoni, Pierre Julius Magistretti

This study shows lactate enhances NMDA receptor currents through redox-sensitive cysteines in GluN2B and CaMKII interactions, linking astrocyte metabolism to synaptic plasticity.

bioRxiv · Nov 21, 2024 · PreprintNeuroscience

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of a-synuclein

Eleanna Kara, Alessandro Crimi, Anne E. Wiedmer, Marc Emmenegger, Claudia Manzoni, Sara Bandrés‐Ciga, Karishma D’Sa, Regina Hertfelder Reynolds, Juan Antonio Botía, Marco Losa, Veronika Lysenko, Manfredi C. Carta, Daniel Heinzer, Merve Avar, Andra Chincisan, , Adriano Aguzzi

The paper identifies 38 genes regulating a-synuclein cell-to-cell transfer using an siRNA screen and shows genetic overlap with Parkinson's disease.

Cell Reports · Jun 1, 2021Peer-reviewedNeuroscience