Author

Hubert Fiumelli

King Abdullah University of Science and TechnologyORCID 0000-0001-5136-3045Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Pierre Julius MagistrettiiD· 2 shared Amanda OoiiD· 1 shared Arnaud TauffenbergeriD· 1 shared Carine BenadibaiD· 1 shared Fabrizio GardoniiD· 1 shared Fouad Lemtiri‐ChliehiD· 1 shared Frank C. SchroederiD· 1 shared Gabriel Herrera‐LópeziD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPhysiology

Pierre Julius MagistrettiORCID

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2 papers

Recent·Most cited

Lactate promotes longevity through redox-driven lipid remodeling in Caenorhabditis elegans.

Arnaud Tauffenberger, Payton J Netherland, Hubert Fiumelli, Joshua D. Meisel, Frank C. Schroeder, Pierre Julius Magistretti

This study shows lactate extends C. elegans lifespan via redox-driven lipid remodeling and involves SIRT1 and RICTOR.

bioRxiv · Sep 25, 2025 · PreprintPhysiology

Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting cysteines in the C-terminal domain of GluN2B subunits: implications for synaptic plasticity

Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh, Lorène Mottier, John Girgis, Carine Benadiba, Pascal Jourdain, Nicolò Carrano, Hanan Mahmood, Amanda Ooi, Stefan T. Arold, Mónica Di Luca, Fabrizio Gardoni, Pierre Julius Magistretti

This study shows lactate enhances NMDA receptor currents through redox-sensitive cysteines in GluN2B and CaMKII interactions, linking astrocyte metabolism to synaptic plasticity.

bioRxiv · Nov 21, 2024 · PreprintNeuroscience