NeurosciencebioRxivPreprint
Loss of PINK1 causes age-dependent mitochondrial trafficking deficits in nigrostriatal dopaminergic neurons through aberrant activation of p38 MAPK
Jingyu Zhao, Yuanxin Chen, Lianteng Zhi…·Chenjian Li
This study shows that PINK1 loss causes age-dependent mitochondrial trafficking deficits in dopaminergic neurons via p38 MAPK hyperactivation, leading to impaired mitochondrial motility and increased oxidative stress.