Author

Yuanxin Chen

Thomas Jefferson UniversityORCID 0009-0002-8237-1907Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Assay:spatial transcriptomics· 3 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Chenbo ZengiD· 2 shared Huaixin Wang· 2 shared Jingyu ZhaoiD· 2 shared Lianteng Zhi· 2 shared Shiquan Cui· 2 shared Chenjian LiiD· 1 shared Hui ZhangiD· 1 shared Hui ZhangiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Chenbo ZengORCID

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Author profile →

4 papers

Recent·Most cited

The Human LRRK2-R1441G Mutation Drives Age-Dependent Oxidative Stress and Mitochondrial Dysfunction in Dopaminergic Neurons

Yuanxin Chen, Lianteng Zhi, Shiquan Cui, Huaixin Wang, Chenbo Zeng, Hui Zhang

This study shows that the LRRK2-R1441G mutation causes age-related mitochondrial dysfunction and oxidative stress in dopamine neurons, suggesting calcium channels and uncoupling proteins as therapeutic targets.

Molecular Neurodegeneration · Jul 7, 2026Peer-reviewedNeuroscience

Quinpirole ameliorates the dysfunction of microglia in human LRRK2-R1441G transgenic mice

Yuanxin Chen, Shiquan Cui, Huaixin Wang, Chenbo Zeng, Hui Zhang

This study shows that quinpirole improves microglial dysfunction in LRRK2-R1441G transgenic mice by reversing motility and responsiveness issues.

bioRxiv · Feb 23, 2025 · PreprintNeuroscience

Loss of PINK1 causes age-dependent mitochondrial trafficking deficits in nigrostriatal dopaminergic neurons through aberrant activation of p38 MAPK

Jingyu Zhao, Yuanxin Chen, Lianteng Zhi, Qing Xu, Hui Zhang, Chenjian Li

This study shows that PINK1 loss causes age-dependent mitochondrial trafficking deficits in dopaminergic neurons via p38 MAPK hyperactivation, leading to impaired mitochondrial motility and increased oxidative stress.

bioRxiv · Jul 17, 2024 · PreprintNeuroscience

Dopamine Release Neuroenergetics in Mouse Striatal Slices

Msema Msackyi, Yuanxin Chen, Wangchen Tsering, Ninghan Wang, Jingyu Zhao, Hui Zhang

This study investigates the neuroenergetics of dopamine release in mouse striatal regions, finding that the dorsal striatum relies more on oxidative phosphorylation while the nucleus accumbens shell relies more on glycolysis.

International Journal of Molecular Sciences · Apr 23, 2024Peer-reviewedNeuroscience