Author

Ai Nguyen

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Organism:virus· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Camden Trent· 2 shared Di Wu· 2 shared Grzegorz PiszczekiD· 2 shared Huaying ZhaoiD· 2 shared Peter SchuckiD· 2 shared Siddhartha AK Datta· 2 shared Agata M Czaja· 1 shared Armin N. AdlyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersBiophysics

Camden Trent

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Intramolecular loops control SARS-CoV-2 nucleocapsid protein self-association and nucleic acid binding dependent on phosphorylation

Ai Nguyen, Siddhartha AK Datta, Camden Trent, Di Wu, Zillay Saleem, Ewa Szczęsna, Wai‐Ming Yau, Felicia Owoborode, Yan Li, Armin N. Adly, Heather R. Kalish, Grzegorz Piszczek, David O. Morgan, Peter Schuck, Huaying Zhao

This study identifies intramolecular loops that regulate SARS-CoV-2 N-protein self-association and nucleic acid binding through phosphorylation-dependent conformational changes.

bioRxiv · May 14, 2026 · PreprintBiophysics

Evolution of a fuzzy ribonucleoprotein complex in viral assembly

Huaying Zhao, Tiansheng Li, Sergio A. Hassan, Ai Nguyen, Siddhartha AK Datta, Guofeng Zhang, Camden Trent, Agata M Czaja, Di Wu, Maria A. Aronova, Kin Kui Lai, Grzegorz Piszczek, Richard D. Leapman, Jonathan Wilson Yewdell, Peter Schuck

The paper investigates how mutations in SARS-CoV-2 N protein affect RNP formation and stability, finding convergent evolution and enhanced RNP assembly in Omicron variants.

eLife · Dec 11, 2025Peer-reviewedBiophysics