Elyssa B. Margolis

The paper maps mu opioid receptor mRNA and protein expression in the habenula of rat and mouse, showing expression in both medial and lateral subdivisions with differences in cell proportions and localization.

This study generates CHCHD2 T61I mutant mice to model Parkinson's disease, finding mitochondrial dysfunction and metabolic shifts towards glycolysis.

The paper shows that acute stress switches KOR signaling from inhibitory to excitatory in a subset of VTA dopamine neurons projecting to the dmPFC, and this effect is mediated by CRF.

This study shows that chronic hyperactivation of midbrain dopamine neurons leads to their preferential degeneration, suggesting increased neural activity may contribute to Parkinson's disease pathology.

The paper identifies electrophysiological and pharmacological differences among VTA glutamate, glutamate-GABA, and GABA neurons using a double transgenic mouse model.

This study evaluates four novel KOR antagonists using electrophysiology in rat midbrain slices, showing differences in their pharmacological effects on dopamine neurons.

The paper identifies a diencephalic circuit involving the lateral habenula and lateral preoptic area that mediates opioid analgesia without reinforcement.

This study investigates the synaptic effects of N/OFQ in VTA neurons using electrophysiology, finding differential modulation based on projection targets and receptor desensitization with repeated application.

This study shows that distinct midbrain dopamine circuits generate incentive value and movement invigoration through functionally heterogeneous signals during Pavlovian conditioning.