Author

Jeffrey A. Bluestone

Gladstone InstitutesORCID 0000-0001-8793-7848Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Alexander MarsoniD· 1 shared Alice Y. K. ChaniD· 1 shared Alyssa C. IndartiD· 1 shared Benjamin G. GoweniD· 1 shared Chun YeiD· 1 shared Dimitre R. SimeonoviD· 1 shared Eric Boyer· 1 shared Frédéric Van Gool· 1 shared

Activity by Year

2016-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperGenetics

Alexander MarsonORCID

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2 papers

Recent·Most cited

ImmunologyThe Journal of Experimental MedicinePeer-reviewedJul 8, 2026

Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy

Alyssa C. Indart, Huiyun Lyu, Vinh Q. Nguyen…·Qizhi Tang

This study develops a receptor-tethered orthogonal IL-2 system to enhance Treg persistence and efficacy in autoimmune diabetes, showing improved survival and therapeutic outcomes.

4 citationstop 2%

mouseproteomics

𝕏 PostBluesky

GeneticsbioRxivPreprintDec 5, 2016

Discovery of an autoimmunity-associated IL2RA enhancer by unbiased targeting of transcriptional activation

Dimitre R. Simeonov, Benjamin G. Gowen, Mandy Y. Boontanrart…·Alexander Marson

The paper identifies an IL2RA enhancer associated with autoimmunity using CRISPRa and shows it affects gene activation timing without blocking expression.

4 citations

humanmouse

𝕏 PostBluesky