Cyril Corbet

This study identifies mitochondrial dysfunction as a key feature of brain senescence in telomerase-deficient mice, linking telomere attrition to impaired mitochondrial function and region-specific neuronal vulnerability.

The paper introduces UCL-MetIsoLib, a high-resolution metabolomics library for isomer-resolved profiling, validated across multiple biological matrices and applied to colorectal cancer organoids.

The paper investigates how mitochondrial DNA variants affect telomere length using transmitochondrial cybrids, finding an inverse correlation between donor telomere length and mitochondrial ROS levels.