Human mitochondrial DNA variants influence telomere length: evidence from a transmitochondrial cybrid model
Manon Mahieu, Jean‐Philippe Defour, Barbara Mathieu, Elena Richiardone, Isaac P. Heremans, Elisa Fabiole, Gabriel Levy, Gabriel Le Berre, Isabelle Scheers, Bénédicte Brichard, Thierry Arnould, Patrick Revy, Guido T. Bommer, Bernard Gallez, Cyril Corbet, Anabelle Decottignies
The paper investigates how mitochondrial DNA variants affect telomere length using transmitochondrial cybrids, finding an inverse correlation between donor telomere length and mitochondrial ROS levels.
bioRxiv · Jun 27, 2025 · PreprintCell Biology