Author

Sneha P. Rath

Broad InstituteORCID 0000-0001-8839-1285Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Vamsi Krishna MoothaiD· 2 shared Arkajit GuhaiD· 1 shared Fangcong DongiD· 1 shared Ruma V. BanerjeeiD· 1 shared Zhu LiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersBiochemistry

Vamsi Krishna MoothaORCID

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2 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedSep 8, 2026

Mitochondrial depolarization stabilizes the vitamin B12 chaperone MMADHC in the cytosol to increase MTR activity

Sneha P. Rath, Zhu Li, Arkajit Guha…·Vamsi Krishna Mootha

The paper identifies MMADHC as a mitochondrial protein that stabilizes in the cytosol upon PMF collapse, increasing MTR activity and one-carbon metabolism.

1 citation

humanproteomics

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Cell BiologybioRxivPreprintOct 27, 2025

The proton motive force maintains mtDNA euploidy by balancing mtDNA replication with cell proliferation

Sneha P. Rath, Vamsi Krishna Mootha

The paper shows that the proton motive force (PMF) balances mtDNA replication and cell proliferation to maintain stable mtDNA copy numbers during cell divisions.

1 citation

humanbulk RNA-seq

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