Author

Fangcong Dong

Broad InstituteORCID 0000-0002-6423-5816Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Vamsi Krishna MoothaiD· 3 shared Rohit SharmaiD· 2 shared Andrew D. PattersoniD· 1 shared Andrew J. AnnaloraiD· 1 shared Arkajit GuhaiD· 1 shared Carolina Mendez· 1 shared Catherine LapriseiD· 1 shared Christine Des RosiersiD· 1 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

Vamsi Krishna MoothaORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Developmental BiologybioRxivPreprintSep 13, 2026

A genetically encoded redox bottleneck constrains human developmental rate

Gabriel E. Valdebenito, Jack P. Madden, Carolina Mendez…·Margarete Díaz-Cuadros

This paper identifies a genetic bottleneck in the G3P shuttle that limits human developmental rate by constraining metabolic flux and the segmentation clock.

DOI 10.64898/2026.09.10.750701

humanbulk RNA-seq

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedSep 8, 2026

Mitochondrial depolarization stabilizes the vitamin B12 chaperone MMADHC in the cytosol to increase MTR activity

Sneha P. Rath, Zhu Li, Arkajit Guha…·Vamsi Krishna Mootha

The paper identifies MMADHC as a mitochondrial protein that stabilizes in the cytosol upon PMF collapse, increasing MTR activity and one-carbon metabolism.

1 citation

humanproteomics

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BiochemistrybioRxivPreprintMay 14, 2026

Interkingdom glycine conjugates of indole-3-carboxylates are Ah receptor ligands

Ethan W. Morgan, Andrew J. Annalora, Denise M. Coslo…·Gary H. Perdew

The paper identifies glycine-conjugated indole-3-carboxylates as AHR ligands, showing human-specific activation and microbial/host-mediated metabolism.

DOI 10.64898/2026.02.13.705761

mousemetabolomics

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BiochemistrybioRxivPreprintFeb 12, 2026

4,5-dihydroxyhexanoic acid is a robust circulating and urine marker of mitochondrial disease and its severity

Owen S. Skinner, María Miranda, Fangcong Dong…·Rohit Sharma

This paper identifies 4,5-dihydroxyhexanoic acid as a biomarker for mitochondrial disease severity and links it to GABA metabolism.

1 citation

humanmetabolomics

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