Cell BiologybioRxivPreprint
Lactate dehydrogenase-induced DNA Topoisomerase 1 is a novel regulator of smooth muscle cell proliferation and remodeling in pulmonary arterial hypertension
Lifeng Jiang, Iryna Zhyvylo, Dmitry A. Goncharov…·Elena A. Goncharova
This study identifies LDHA-lactate-induced over-lactylation and TOP1 accumulation as drivers of PASMC hyper-proliferation and PAH, with TOP1 inhibition reversing these effects.
DOI 10.1101/2025.11.10.687749