Serotonin signals through ciliary 5-HT6 to control insulin secretion
Shannon E Townsend, Jeong Hun Jo, Morgan Opp, Katherine Bates, Xinhang Dong, Jing W. Hughes
This study shows that the 5-HT6 receptor in pancreatic beta cells, localized to cilia, enhances insulin secretion, highlighting ciliary localization as a key determinant of GPCR function.
bioRxiv · Nov 3, 2026 · PreprintCell Biology