Jing W. Hughes

This study shows that the 5-HT6 receptor in pancreatic beta cells, localized to cilia, enhances insulin secretion, highlighting ciliary localization as a key determinant of GPCR function.

The paper shows primary cilia use localized glycolysis and mitochondrial PEP to generate ATP, and can access ATP from the cell body when glucose is limited.

This study shows primary cilia are essential for GLP-1R signaling in pancreatic beta cells, as their loss impairs insulin secretion and cAMP/Ca2+ responses.

This study investigates how mu opioid receptors (MOPRs) in mouse islets affect cell signaling and hormone secretion, finding they modulate calcium dynamics and glucagon release.

This study uses ultrastructure expansion microscopy to visualize axonemal dynein in pancreatic islet primary cilia, showing DNAI1 as a key subunit.

This study shows that the α-cell mitochondrial PEP cycle senses amino acids and regulates Ca2+ levels without affecting glucagon secretion.

The paper uses intravital imaging to show glucose-dependent cilia movement in live mouse pancreatic islets.

This study uses immuno-SEM to identify specific proteins on primary cilia of mouse and human pancreatic islets, overcoming limitations of conventional imaging methods.