Author
Yale UniversityORCID 0000-0001-9171-8031Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Shannon E Townsend, Jeong Hun Jo, Morgan Opp…·Jing W. Hughes
This study shows that the 5-HT6 receptor in pancreatic beta cells, localized to cilia, enhances insulin secretion, highlighting ciliary localization as a key determinant of GPCR function.
Isabella Melena, Jeong Hun Jo, Shannon E. Townsend…·Jing W. Hughes
This study shows primary cilia are essential for GLP-1R signaling in pancreatic beta cells, as their loss impairs insulin secretion and cAMP/Ca2+ responses.
Michael Keith, Christine Stander, Diego De Gregorio…·Daniel C. Castro
This study investigates how mu opioid receptors (MOPRs) in mouse islets affect cell signaling and hormone secretion, finding they modulate calcium dynamics and glucagon release.