Xinhang Dong

This study shows that the 5-HT6 receptor in pancreatic beta cells, localized to cilia, enhances insulin secretion, highlighting ciliary localization as a key determinant of GPCR function.

The paper shows primary cilia use localized glycolysis and mitochondrial PEP to generate ATP, and can access ATP from the cell body when glucose is limited.

This study shows primary cilia are essential for GLP-1R signaling in pancreatic beta cells, as their loss impairs insulin secretion and cAMP/Ca2+ responses.

This study shows that the α-cell mitochondrial PEP cycle senses amino acids and regulates Ca2+ levels without affecting glucagon secretion.